Faculty Scholarly Dissemination Grants

Title

SCREENING THE EFFECTS OF GENE OVEREXPRESSION ON THE DEVELOPING CHICK MIDBRAIN WITH UNDERGRADUATE RESEARCHERS

Department

Biomedical Sciences

College

College of Liberal Arts and Sciences

Disciplines

Medicine and Health Sciences

Abstract

The chick embryonic midbrain offers an effective model to monitor the effects of gene overexpression or knockdown on neural progenitor differentiation at multiple different points during development. To better characterize the effect of gene manipulation by in ovoelectroporation, we are using quantitative PCR to screen the effect of gene overexpression on markers of neural progenitor differentiation, followed by anatomical analysis of interesting candidate genes. These approaches are undertaken with undergraduate researchers, providing an optimal forum to reinforce principles of developmental biology and also to identify and characterize unknown genes or genetic mutants. These approaches can be applied broadly to allow investigators to readily screen for changes in neural progenitor differentiation.

Conference Name

Society for Neuroscience

Conference Location

New Orleans

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