Faculty Scholarly Dissemination Grants

Title

Facile Synthesis of Arylsulfonates and Exploration of their Use in Sonogashira and Ullman Cross-Coupling Reactions

Department

Chemistry Department

College

College of Liberal Arts and Sciences

Disciplines

Physical Sciences and Mathematics

Abstract

The C-O bond of phenol can be activated by reaction with arylsulfonyl chlorides, to make the corresponding arylsulfonates that can be used in subsequent reactions. Facile synthesis of different arylsulfonates from various arylsulfonyl chlorides and phenol are reported. What is unique about the synthesis is that very good to excellent yields of arylsulfonates were obtained without the use of column chromatography. A more efficient purification technique was developed based on crystallization. Initial experiments are underway to test the different arylsulfonates as alternative substrates for Sonogashira and Ullman cross-coupling reactions.

Conference Name

248th National Meeting of the American Chemical Society

Conference Location

San Francisco, CA

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