Exploring Important Protein Interactions in the Mammalian Diaphanous-related Formins: A Closer Look at the Relationship between the Intracellular Skeletal Network and a Single Amino Acid Residue

Brent Hehl, Grand Valley State University

Abstract

The Diaphanous-related formin protein family plays a key role in intracellular cytoskeletal regulation. Due to their farreaching importance, these proteins must be highly regulated themselves. With recent exploration of regulatory processes of mDia2, a formin protein found in mammals, the established mechanism of control appears to be more complex than previously thought. This project examines the possibility of phosphorylation at critical sites near the protein regions that regulate formin function. Here, we outline our initial screen for discovering these specific residues within mDia2 and their potential for phosphorylation using site-directed mutagenesis.

Recommended Citation

Hehl, Brent (2006) "Exploring Important Protein Interactions in the Mammalian Diaphanous-related Formins: A Closer Look at the Relationship between the Intracellular Skeletal Network and a Single Amino Acid Residue," McNair Scholars Journal: Vol. 10: Iss. 1, Article 9.
Available at: http://scholarworks.gvsu.edu/mcnair/vol10/iss1/9