We examined 70 abnormal psychology textbooks published from 1920s to the present to identify consistent cross-cultural themes with regard to human depressive experiences over time and across regions of the world. The cultural and cross-cultural literature on abnormality and depression, in particular, has contributed to widening the scope of abnormal psychology textbooks over time. However, the texts are almost entirely dependent on Western diagnostic categories, particularly with regard to definitions of depression. Within the Western classification framework, authors of abnormal psychology textbooks have increasingly recognized the role of culture in depressive experiences and their communication. On the basis of our content analysis of the textbooks, we propose 10 culturally informed questions to study the relationship between culture and depression.