Event Title
Regioselectivity of Aziridine Ring Opening Reactions Using Hydroxyl Compounds
Presentation Type
Poster/Portfolio
Presenter Major(s)
Chemistry
Mentor Information
Matthew Hart, hartm@gvsu.edu
Department
Chemistry
Location
Henry Hall Atrium 86
Start Date
13-4-2011 1:00 PM
End Date
13-4-2011 2:00 PM
Keywords
Health and Wellness, Health, Illness, and Healing, Life Science, Physical Science, Technology
Abstract
Thyroid hormone (TH) related disorders plague much of the world's population with limited treatment options. T1AM, a naturally occurring metabolite of the TH, is an effective agonist of the Trace Amine Associated Receptor 1 (TAAR1) and exhibits physiological effects that counter those of the TH. The existence of a regulatory relationship between T1AM and the TH is, therefore, likely. Elucidation of this relationship requires better understanding of TAAR1 regulation and could lead to more comprehensive treatment options. Previously our lab demonstrated agonist/antagonist regulation of TAAR1 using the two enantiomers of apomorphine. The project described herein examines the regioselectivity of aziridine ring opening reactions using hydroxyl compounds in both acidic and nucleophilic conditions. The goal of this project is to implement this chemistry to synthesize conformationally restricted analogs of T1AM that will exhibit TAAR1 regulations similar to that observed with apomorphine.
Regioselectivity of Aziridine Ring Opening Reactions Using Hydroxyl Compounds
Henry Hall Atrium 86
Thyroid hormone (TH) related disorders plague much of the world's population with limited treatment options. T1AM, a naturally occurring metabolite of the TH, is an effective agonist of the Trace Amine Associated Receptor 1 (TAAR1) and exhibits physiological effects that counter those of the TH. The existence of a regulatory relationship between T1AM and the TH is, therefore, likely. Elucidation of this relationship requires better understanding of TAAR1 regulation and could lead to more comprehensive treatment options. Previously our lab demonstrated agonist/antagonist regulation of TAAR1 using the two enantiomers of apomorphine. The project described herein examines the regioselectivity of aziridine ring opening reactions using hydroxyl compounds in both acidic and nucleophilic conditions. The goal of this project is to implement this chemistry to synthesize conformationally restricted analogs of T1AM that will exhibit TAAR1 regulations similar to that observed with apomorphine.