Event Title
Towards the Synthesis of Novel Cyclic Heterocyclic Compounds to Interact with Higher-Order DNA
Presentation Type
Poster/Portfolio
Presenter Major(s)
Biomedical Sciences
Mentor Information
Toni Rice, riceto@gvsu.edu
Department
Chemistry
Location
Henry Hall Atrium 78
Start Date
13-4-2011 10:00 AM
End Date
13-4-2011 11:00 AM
Keywords
Life Science
Abstract
Higher-order DNA conformations can form within regions of DNA rich in guanines. Telomeric DNA, located at the end of human chromosomes is guanine-rich and can fold into tetraplex DNA. Compounds that should interact and stabilize telomeric DNA are being developed to increase binding affinity and selectively over duplex DNA. Efforts towards the convergent synthesis of novel, cyclic compounds will be described in this presentation. Intermediate heterocyclic monomeric units were synthesized using a building block approach involving acid chloride-amine coupling reactions. The final cyclization reaction will be attempted via the use of peptide coupling reagents. These coupling reagents will be used in combination with the cation-template effect, to minimize polymerization reactions. WebMO calculations are being performed to help design energetically favorable compounds. The synthetic and computational results obtained to date will be presented.
Towards the Synthesis of Novel Cyclic Heterocyclic Compounds to Interact with Higher-Order DNA
Henry Hall Atrium 78
Higher-order DNA conformations can form within regions of DNA rich in guanines. Telomeric DNA, located at the end of human chromosomes is guanine-rich and can fold into tetraplex DNA. Compounds that should interact and stabilize telomeric DNA are being developed to increase binding affinity and selectively over duplex DNA. Efforts towards the convergent synthesis of novel, cyclic compounds will be described in this presentation. Intermediate heterocyclic monomeric units were synthesized using a building block approach involving acid chloride-amine coupling reactions. The final cyclization reaction will be attempted via the use of peptide coupling reagents. These coupling reagents will be used in combination with the cation-template effect, to minimize polymerization reactions. WebMO calculations are being performed to help design energetically favorable compounds. The synthetic and computational results obtained to date will be presented.