Event Title
Design of Novel Cyclic Heterocyclic Compounds to Interact with Higher-Order DNA
Presentation Type
Poster/Portfolio
Presenter Major(s)
Chemistry
Mentor Information
Mary Karpen, karpenm@gvsu.edu; Toni Rice, riceto@gvsu.edu
Department
Chemistry
Location
Kirkhof Center KC56
Start Date
13-4-2011 12:00 PM
End Date
13-4-2011 1:00 PM
Keywords
Creativity/ Innovation, Life Science, Physical Science
Abstract
Macrocycles that bind to the ends of DNA, called telomeres, may be useful in treating cancer by limiting cell division. In this study, we explore a modular approach to designing macrocycles that can be synthesized using acid chloride-amine coupling reactions. By mixing and matching heterocyclic subunits, we constructed computational models of various macrocycles. The stability of these models was determined using semi-empirical calculations. Potentially stable models were used to direct experimentalists in their synthesis.
Design of Novel Cyclic Heterocyclic Compounds to Interact with Higher-Order DNA
Kirkhof Center KC56
Macrocycles that bind to the ends of DNA, called telomeres, may be useful in treating cancer by limiting cell division. In this study, we explore a modular approach to designing macrocycles that can be synthesized using acid chloride-amine coupling reactions. By mixing and matching heterocyclic subunits, we constructed computational models of various macrocycles. The stability of these models was determined using semi-empirical calculations. Potentially stable models were used to direct experimentalists in their synthesis.