Event Title
Effect of Altered Gravity on Rat Mammary Epithelial Cell Proliferation
Presentation Type
Poster/Portfolio
Presenter Major(s)
Cell and Molecular Biology
Mentor Information
Osman Patel, patelo@gvsu.edu
Department
Cell and Molecular Biology
Location
Kirkhof Center KC29
Start Date
13-4-2011 9:00 AM
End Date
13-4-2011 10:00 AM
Keywords
Environment, Health and Wellness, Life Science, Technology
Abstract
If the human race is ever to expand into space, humans will be required to reproduce in low gravity. Data collected to date reveals that altered gravity environment impairs lipogenesis in a lactating mammary gland. However, accelerated growth of the secretory epithelium of the mammary gland takes place during pregnancy. Therefore, the objective of this study is to determine the effects of hypergravity exposure from mid- to late pregnancy on pre-partum morphogenesis of the mammary gland epithelium. Pregnant rats were exposed to either 2g or 1g from days 11 to 20 of gestation (G20). Mammary tissue was collected at G20 and processed for antibody directed staining. Immunolocalization studies of Caspase 3 and P53 in HG exposed and control rats are completed and data from structure and component analysis will be presented.
Effect of Altered Gravity on Rat Mammary Epithelial Cell Proliferation
Kirkhof Center KC29
If the human race is ever to expand into space, humans will be required to reproduce in low gravity. Data collected to date reveals that altered gravity environment impairs lipogenesis in a lactating mammary gland. However, accelerated growth of the secretory epithelium of the mammary gland takes place during pregnancy. Therefore, the objective of this study is to determine the effects of hypergravity exposure from mid- to late pregnancy on pre-partum morphogenesis of the mammary gland epithelium. Pregnant rats were exposed to either 2g or 1g from days 11 to 20 of gestation (G20). Mammary tissue was collected at G20 and processed for antibody directed staining. Immunolocalization studies of Caspase 3 and P53 in HG exposed and control rats are completed and data from structure and component analysis will be presented.