Event Title
Monte Carlo Simulations of Cerenkov Luminescence Imaging
Presentation Type
Oral and/or Visual Presentation
Presenter Major(s)
Physics
Mentor Information
Anthony Chang, Richard Vallery
Department
Van Andel Institute, Physics
Location
Kirkhof Center 1142
Start Date
11-4-2012 11:30 AM
Keywords
Health, Life Science, Physical Science
Abstract
As Cerenkov Luminescence Imaging becomes more prevalent in the field of pre-clinical imaging, computer simulations must be done in order to investigate the method. In this study, simulations are done parallel to PET and Cerenkov Luminescence Imaging data. The results of these simulations will be used to test what regions of mice are the most ideal to plant sub-cutaneous tumors and get good signal. PET data for mice injected with 18F-Fluorodeoxy-glucose (FDG) was used to determine the number of events that occurred in given regions of interest. An event is defined as a decay of the radioisotope. More events will take place in regions of high metabolism, so our regions of interest included the gut, the bladder, the brain, and the heart. The simulations clearly demonstrated that signal from the heart is very minimal compared to that of the gut or the brain, so this mid-section of mice is the most ideal for the injection of subcutaneous tumors.
Monte Carlo Simulations of Cerenkov Luminescence Imaging
Kirkhof Center 1142
As Cerenkov Luminescence Imaging becomes more prevalent in the field of pre-clinical imaging, computer simulations must be done in order to investigate the method. In this study, simulations are done parallel to PET and Cerenkov Luminescence Imaging data. The results of these simulations will be used to test what regions of mice are the most ideal to plant sub-cutaneous tumors and get good signal. PET data for mice injected with 18F-Fluorodeoxy-glucose (FDG) was used to determine the number of events that occurred in given regions of interest. An event is defined as a decay of the radioisotope. More events will take place in regions of high metabolism, so our regions of interest included the gut, the bladder, the brain, and the heart. The simulations clearly demonstrated that signal from the heart is very minimal compared to that of the gut or the brain, so this mid-section of mice is the most ideal for the injection of subcutaneous tumors.