Event Title
The Development of a Novel Gadolinium Chelating Agent for MRI Contrast Agents Employing Carbamoylmethyl-Phosphine Oxides (CMPOs)
Presentation Type
Poster/Portfolio
Presenter Major(s)
Biomedical Sciences
Mentor Information
Shannon Biros
Department
Chemistry
Location
Kirkhof Center KC27
Start Date
11-4-2012 9:00 AM
Keywords
Information, Innovation, and Technology
Abstract
Ionized gadolinium (Gd) is a potent contrast agent used in medical resonance imaging (MRI). As gadolinium is a nephrotoxin, chelating agents are needed to prevent toxicity to the patient. Current chelating agents are available; however, they suffer from a lack of water solubility or by having a negative affect on water's relaxivity rates. An ideal chelating agent binds well to Gd while allowing it to simultaneously interact with individual water molecules. Our lab is developing a novel class of chelating agents containing carbamoylmethyl phosphine oxides (CMPO's), which have the potential to be more soluble in water than current commercially available agents while retaining a favorable affect on water relaxivity.
The Development of a Novel Gadolinium Chelating Agent for MRI Contrast Agents Employing Carbamoylmethyl-Phosphine Oxides (CMPOs)
Kirkhof Center KC27
Ionized gadolinium (Gd) is a potent contrast agent used in medical resonance imaging (MRI). As gadolinium is a nephrotoxin, chelating agents are needed to prevent toxicity to the patient. Current chelating agents are available; however, they suffer from a lack of water solubility or by having a negative affect on water's relaxivity rates. An ideal chelating agent binds well to Gd while allowing it to simultaneously interact with individual water molecules. Our lab is developing a novel class of chelating agents containing carbamoylmethyl phosphine oxides (CMPO's), which have the potential to be more soluble in water than current commercially available agents while retaining a favorable affect on water relaxivity.