Event Title
Investigating the Role of Nrg1p and Tup1p During Candida albicans Chlamydospore Formation
Presentation Type
Poster/Portfolio
Presenter Major(s)
Biomedical Sciences
Mentor Information
Derek Thomas
Department
Biomedical Sciences
Location
Kirkhof Center KC30
Start Date
11-4-2012 9:00 AM
Keywords
Life Science
Abstract
Candidiasis represents the fourth most frequent nosocomial infection both in the US and worldwide. Candida albicans can grow as yeast cells, pseudohyphae or hyphae and produce chlamydospores with its form being dictated by its surrounding conditions. The ability to form hyphal cells has been fundamentally linked to the disease potential of this organism. Nrg1p is a global repressor of the filamentation process of C. albicans and associates with the co-repressor Tup1p during this inhibition of filamentation. Nrg1p has also been shown to play a key role in chlamydospore formation, but the relevance of Tup1p is unknown. In this study we describe differences in the nature of Nrg1p dependent regulation of chlamydospore formation compared to that of filamentation and offer further insights into the functions of Nrg1p in C. albicans. Furthermore we establish that chlamydospore formation is independent of Tup1p.
Investigating the Role of Nrg1p and Tup1p During Candida albicans Chlamydospore Formation
Kirkhof Center KC30
Candidiasis represents the fourth most frequent nosocomial infection both in the US and worldwide. Candida albicans can grow as yeast cells, pseudohyphae or hyphae and produce chlamydospores with its form being dictated by its surrounding conditions. The ability to form hyphal cells has been fundamentally linked to the disease potential of this organism. Nrg1p is a global repressor of the filamentation process of C. albicans and associates with the co-repressor Tup1p during this inhibition of filamentation. Nrg1p has also been shown to play a key role in chlamydospore formation, but the relevance of Tup1p is unknown. In this study we describe differences in the nature of Nrg1p dependent regulation of chlamydospore formation compared to that of filamentation and offer further insights into the functions of Nrg1p in C. albicans. Furthermore we establish that chlamydospore formation is independent of Tup1p.