Event Title
Changes in Vascular Reactivity of Mesenteric Porcine Arteries Following Hyperbaric Treatment
Presentation Type
Poster/Portfolio
Presenter Major(s)
Biomedical Sciences
Mentor Information
Francis Sylvester
Department
Biomedical Sciences
Location
Kirkhof Center KC7
Start Date
11-4-2012 9:00 AM
Keywords
Health
Abstract
The objective of this study was to evaluate the changes in vascular reactivity of mesenteric arteries resulting from hyperbaric oxygen treatment. It was hypothesized that hyperbaric oxygen treatment differentially alters vascular reactivity in mesenteric arteries. Arteries from porcine mesentery were dissected and then subjected to a 2-hour hyperbaric treatment in 100% oxygen, 100% nitrogen, or room air at 1.75 ATA. Following a 1-hour equilibration in Krebs-Henseleit solution arteries were treated with potassium chloride to assess viability. Subsequently, arteries were treated with increasing concentrations of phenylephrine and then sodium nitroprusside to measure changes in vascular reactivity. Treatment with hyperbaric oxygen augmented vascular responses to phenylephrine and sodium nitroprusside when compared to arteries treated with hyperbaric nitrogen. The results from these studies provide basic insight into the physiological effects of hyperbaric oxygen treatment.
Changes in Vascular Reactivity of Mesenteric Porcine Arteries Following Hyperbaric Treatment
Kirkhof Center KC7
The objective of this study was to evaluate the changes in vascular reactivity of mesenteric arteries resulting from hyperbaric oxygen treatment. It was hypothesized that hyperbaric oxygen treatment differentially alters vascular reactivity in mesenteric arteries. Arteries from porcine mesentery were dissected and then subjected to a 2-hour hyperbaric treatment in 100% oxygen, 100% nitrogen, or room air at 1.75 ATA. Following a 1-hour equilibration in Krebs-Henseleit solution arteries were treated with potassium chloride to assess viability. Subsequently, arteries were treated with increasing concentrations of phenylephrine and then sodium nitroprusside to measure changes in vascular reactivity. Treatment with hyperbaric oxygen augmented vascular responses to phenylephrine and sodium nitroprusside when compared to arteries treated with hyperbaric nitrogen. The results from these studies provide basic insight into the physiological effects of hyperbaric oxygen treatment.