Event Title
Faster-than-light Advancement into Cerenkov Luminescence Imaging
Presentation Type
Oral and/or Visual Presentation
Mentor Information
Anthony Chang
Department
Van Andel Institute
Location
Kirkhof Center 2259
Start Date
10-4-2013 12:00 AM
End Date
10-4-2013 12:00 AM
Keywords
Life Science, Physical Science
Abstract
Purpose: Cerenkov radiation (CR) is the visible light emission that occurs when a charged particle, such as a ²+ or ²-, exceeds the speed of light in a medium. CR can be detected by an optical imager with appropriate sensitivity. This study is to develop standard protocols for testing the feasibility of optical imagers for Cerenkov Luminescence Imaging (CLI), and then to utilize the protocols to assess if the AMI-1000 is an appropriate device for CLI. Methods: Two positron emitters (18F, 64Cu) were used to investigate the quality of the AMI-1000. Studies included linearity between radiance and radioactivity, spectrum, signal homogeneity across a source of uniform intensity, spatial resolution, and the in vivo and in vitro correlation between CLI and Positron Emission Tomography (PET). Results: A protocol for testing optical imagers for CLI was successfully developed. Our results in each of these areas demonstrate that the AMI-1000 is a viable optical imager for CLI.
Faster-than-light Advancement into Cerenkov Luminescence Imaging
Kirkhof Center 2259
Purpose: Cerenkov radiation (CR) is the visible light emission that occurs when a charged particle, such as a ²+ or ²-, exceeds the speed of light in a medium. CR can be detected by an optical imager with appropriate sensitivity. This study is to develop standard protocols for testing the feasibility of optical imagers for Cerenkov Luminescence Imaging (CLI), and then to utilize the protocols to assess if the AMI-1000 is an appropriate device for CLI. Methods: Two positron emitters (18F, 64Cu) were used to investigate the quality of the AMI-1000. Studies included linearity between radiance and radioactivity, spectrum, signal homogeneity across a source of uniform intensity, spatial resolution, and the in vivo and in vitro correlation between CLI and Positron Emission Tomography (PET). Results: A protocol for testing optical imagers for CLI was successfully developed. Our results in each of these areas demonstrate that the AMI-1000 is a viable optical imager for CLI.