Event Title
Effect of L-tyrosine Supplementation on the Muscle Metaboreflex Response
Presentation Type
Poster/Portfolio
Presenter Major(s)
Biomedical Sciences
Mentor Information
James Lang
Department
Movement Science
Location
Henry Hall Atrium 52
Start Date
10-4-2013 3:00 PM
End Date
10-4-2013 4:00 PM
Keywords
Health
Abstract
The muscle metaboreflex functions to increase sympathetic activity in response to the generation of vasoactive metabolites from working skeletal muscle. The resulting blood pressure response is dependent on catecholamine synthesis in synaptic nerve terminals. We hypothesize that oral supplementation of L-tyrosine, the primary substrate for catecholamine biosynthesis, will increase or maintain blood pressure response during metaboreflex activation. Subjects will ingest 150mg/kg of tyrosine prior to performing static handgrip exercise for 2 minutes. Before ending exercise, an arm cuff will be inflated to suprasystolic pressure to arrest blood flow to the forearm. Heart rate and blood pressure were measured throughout the procedure. We anticipate that compared to placebo, heart rate and blood pressure will be elevated as a result of tyrosine supplementation. This suggests that tyrosine is limiting the full expression of effector response to sympathetic activation in young adults.
Effect of L-tyrosine Supplementation on the Muscle Metaboreflex Response
Henry Hall Atrium 52
The muscle metaboreflex functions to increase sympathetic activity in response to the generation of vasoactive metabolites from working skeletal muscle. The resulting blood pressure response is dependent on catecholamine synthesis in synaptic nerve terminals. We hypothesize that oral supplementation of L-tyrosine, the primary substrate for catecholamine biosynthesis, will increase or maintain blood pressure response during metaboreflex activation. Subjects will ingest 150mg/kg of tyrosine prior to performing static handgrip exercise for 2 minutes. Before ending exercise, an arm cuff will be inflated to suprasystolic pressure to arrest blood flow to the forearm. Heart rate and blood pressure were measured throughout the procedure. We anticipate that compared to placebo, heart rate and blood pressure will be elevated as a result of tyrosine supplementation. This suggests that tyrosine is limiting the full expression of effector response to sympathetic activation in young adults.