Event Title
The Effects of Methylcholine and Hyperbaric Oxygen Therapy on Porcine Renal Arteries
Presentation Type
Poster/Portfolio
Presenter Major(s)
Biomedical Sciences
Mentor Information
Francis Sylvester
Department
Biomedical Sciences
Location
Henry Hall Atrium 18
Start Date
10-4-2013 9:00 AM
End Date
10-4-2013 10:00 AM
Keywords
Health, Physical Science
Abstract
Nitric oxide is released by blood vessels to mediate vasodilation (i.e. vessel relaxation). Typically, nitric oxide is synthesized by the endothelium of blood vessels in response to various stimuli including acetylcholine or its analog, methylcholine. As a gaseous molecule, nitric oxide diffuses to adjacent vascular smooth muscle cells inducing vasodilation. Hyperbaric oxygen therapy may alter the effects of nitric oxide on the vasculature. The purpose of this study is to determine the effects of hyperbaric oxygen therapy on methylcholine-induced vasodilation in porcine renal arteries. Arteries will be dissected, placed in a hyperbaric chamber for 2 hours, mounted in isolated organ baths, and responses to phenylephrine (a vasoconstrictor) and methylcholine will be recorded. Responses consist of changes in tension as measured by a force transducer. These results will provide insight on the effects of hyperbaric oxygen therapy on a clinically important vascular control mechanism.
The Effects of Methylcholine and Hyperbaric Oxygen Therapy on Porcine Renal Arteries
Henry Hall Atrium 18
Nitric oxide is released by blood vessels to mediate vasodilation (i.e. vessel relaxation). Typically, nitric oxide is synthesized by the endothelium of blood vessels in response to various stimuli including acetylcholine or its analog, methylcholine. As a gaseous molecule, nitric oxide diffuses to adjacent vascular smooth muscle cells inducing vasodilation. Hyperbaric oxygen therapy may alter the effects of nitric oxide on the vasculature. The purpose of this study is to determine the effects of hyperbaric oxygen therapy on methylcholine-induced vasodilation in porcine renal arteries. Arteries will be dissected, placed in a hyperbaric chamber for 2 hours, mounted in isolated organ baths, and responses to phenylephrine (a vasoconstrictor) and methylcholine will be recorded. Responses consist of changes in tension as measured by a force transducer. These results will provide insight on the effects of hyperbaric oxygen therapy on a clinically important vascular control mechanism.