Event Title
Progress Towards the Synthesis of Novel Urea Derivatives of T1AM
Presentation Type
Poster/Portfolio
Presenter Major(s)
Chemistry
Mentor Information
Matthew Hart
Department
Chemistry
Location
Henry Hall Atrium 85
Start Date
10-4-2013 2:00 PM
End Date
10-4-2013 3:00 PM
Keywords
Information, Innovation, and Technology, Health, Life Science, Physical Science
Abstract
The thyroid hormone (TH) is excreted by the thyroid gland and plays a pivotal role in organism development and metabolism. Recent research has shown that a metabolite of TH, 3-iodothyronamine (T1AM) is able to evoke biochemical responses in mice, such as hypothermia and cardiac fluctuation in opposition to the effects of TH. T1AM is a known agonist of the trace amine associated receptor (TAAR). Chemical alterations of T1AM may be able to augment these effects and may lead to greater understanding of the role of TAAR in thyroid hormone biology. Specifically, this project examines the incorporation of a urea linkage and altering the substitution pattern on one of the rings of T1AM to an ortho arrangment. Product verification will be done using NMR techniques and HPLC analysis. Once completed, these compounds will be evaluated in cell culture assays using a Hithunter cAMP assay. Progress towards this goal is described herein.
Progress Towards the Synthesis of Novel Urea Derivatives of T1AM
Henry Hall Atrium 85
The thyroid hormone (TH) is excreted by the thyroid gland and plays a pivotal role in organism development and metabolism. Recent research has shown that a metabolite of TH, 3-iodothyronamine (T1AM) is able to evoke biochemical responses in mice, such as hypothermia and cardiac fluctuation in opposition to the effects of TH. T1AM is a known agonist of the trace amine associated receptor (TAAR). Chemical alterations of T1AM may be able to augment these effects and may lead to greater understanding of the role of TAAR in thyroid hormone biology. Specifically, this project examines the incorporation of a urea linkage and altering the substitution pattern on one of the rings of T1AM to an ortho arrangment. Product verification will be done using NMR techniques and HPLC analysis. Once completed, these compounds will be evaluated in cell culture assays using a Hithunter cAMP assay. Progress towards this goal is described herein.