Synthesis and Fluorescence Properties of C-6 Modified 2’Deoxynucleosides
College of Liberal Arts and Sciences
The synthesis of C-6 modified 2-deoxyadenosine and 2-deoxyguanosine is reported. Two synthetic strategies were employed for the introduction of the alkynyl moiety on the C-6 position of 2-deoxynucleosides by Pd-catalyzed cross-coupling methods. The fluorescence properties of these novel alkynylated 2-deoxyadenosine and 2-deoxyguanosine analogs have been determined. The results of our preliminary studies will be presented.
242nd National Meeting of the American Chemical Society
Ngassa, Felix; Gabrielli, Alexandra; Wingellar, Maxwell; MacRae, Matt; and Nwokocha, Goodwill, "Synthesis and Fluorescence Properties of C-6 Modified 2’Deoxynucleosides" (2011). Faculty Scholarly Dissemination Grants. 414.