Date of Award
Medical Dosimetry (M.S.)
Diagnostic & Treatment Sciences
Introduction: Hypofractionated treatment delivery regimens are associated with better overall long-term disease control for prostate cancer. For patients with high-risk disease, there may be an indication for treatment of the surrounding pelvic lymph nodes for better over-all disease control. In order to achieve a hypofractionated regimen with treatment to the surrounding pelvic lymph nodes a simultaneous integrated boost technique is employed. There are concerns regarding achievability of target dose coverage and limitation of dose to the surrounding organs at risk with this fractionation.
Methods: This study is a retrospective dosimetric analysis of 7 randomly selected patients with high-risk prostate cancer. Each patient had a CT simulation performed, and two comparative treatment plans created, one with a conventional technique, the other with a hypofractionated technique.
Results: The results indicated that there was not a significant difference between target dose coverage and dose to surrounding organs at risk with the use of a hypofractionated treatment regimen with simultaneous integrated boost as compared to a conventional regimen with sequential boost. Use of a hypofractionated regimen with simultaneous integrated boost is a viable regimen to choose for patients with prostate cancer and indication of need for radiation to the surrounding pelvic lymph nodes.
Conclusion: Hypofractionated treatment regimens offer patients better long-term biochemical disease-free survival. Although patients may experience acute side effects earlier, and at an increased level, those side effects typically resolve more quickly than with conventional treatment delivery.
Sammon, Kristina, "Dosimetric Comparison of Hypofractionated Prostate Radiation with Simultaneous Integrated Boost and Conventional Fractionation with Sequential Boost" (2020). Masters Projects. 11.