Graduate Degree Type
Medical Dosimetry (M.S.)
Malissa Randolph R.T.(T) CMD
The aim of this study was to investigate if using reference point normalization versus volumetric normalization makes a difference in plan homogeneity and high dose control in 3D whole right breast radiation treatment planning.
Ten previously treated right breast patients were each planned four different ways: eComp volumetric normalization, eComp reference point normalization, FIF volumetric normalization, FIF reference point normalization. All plans had 95% of volume covered by 95% of prescription, to compare normalization technique outcome. Homogeneity index (HI), maximum dose 0.03cc, mean dose to the breast PTV eval, minimum dose to the breast PTV eval, and mean dose to the right lung were measured for all 40 plans.
Plans with volumetric normalization had statistically significant better means for HI , maximum dose 0.03cc , and mean dose to the breast PTV eval . Plans that used eComp had statistically significantly better means for HI , maximum dose 0.03cc , mean dose to the breast PTV eval , and right lung mean dose . Some of the dose metrics measured showed that regardless of planning technique used (eComp or FIF), volumetric normalization plans had means that were statistically superior to point based normalization plans.
The study showed that there is a statistically significant difference in plan homogeneity and high dose control based on normalization technique for 3D right breast plans. Further investigations should be performed to determine if volumetric normalization techniques should be used for 3D planning.
Graham, Stephanie Lyn, "3D Right Breast Treatments: A Comparison of Volumetric and Reference Point Normalization Techniques." (2022). Culminating Experience Projects. 191.