Keywords

Leukemia, Acute Lymphoblastic Leukemia, Chimeric Antigen Receptor T-Cell Therapy

Disciplines

Oncology | Pediatrics

Mentor

Dr. Frank Sylvester

Abstract

Acute Lymphoblastic Leukemia (ALL) is the most commonly diagnosed pediatric cancer and the most frequent cancer-induced cause of death among young people. Despite this fact, tremendous progress in treating the disease has been made in the last 50 years. This systematic literature review examines the incidence of the disease as well as the importance of risk stratification in treatment planning. The role of genetics in ALL risk stratification, specifically hypodiploidy and hyperdiploidy, is also considered. Finally, current treatment protocols, treatment failure, and the future of research and treatments are all each examined.

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