Event Title
Synthesis and Fluorescence Analysis of C-6 Modified 2'-Deoxynucleosides
Presentation Type
Poster/Portfolio
Presenter Major(s)
Biomedical Sciences, Chemistry
Mentor Information
Felix Ngassa, ngassaf@gvsu.edu
Department
Chemistry
Location
Henry Hall Atrium 7
Start Date
13-4-2011 11:00 AM
End Date
13-4-2011 12:00 PM
Keywords
Life Science
Abstract
The synthesis of C-6 modified 2'-deoxyadenosine and 2'-deoxyguanosine is reported. Two synthetic strategies were employed for the introduction of the alkynyl moiety on the C-6 position of 2'-deoxynucleosides by Pd-catalyzed cross-coupling methods. The fluorescence properties of these novel alkynylated 2'-deoxyadenosine and 2'-deoxyguanosine analogs have been determined. The results of our preliminary studies will be presented.
Synthesis and Fluorescence Analysis of C-6 Modified 2'-Deoxynucleosides
Henry Hall Atrium 7
The synthesis of C-6 modified 2'-deoxyadenosine and 2'-deoxyguanosine is reported. Two synthetic strategies were employed for the introduction of the alkynyl moiety on the C-6 position of 2'-deoxynucleosides by Pd-catalyzed cross-coupling methods. The fluorescence properties of these novel alkynylated 2'-deoxyadenosine and 2'-deoxyguanosine analogs have been determined. The results of our preliminary studies will be presented.