Event Title
Toward the Synthesis of Cyclic Heterocyclic Polyamides as Tetraplex DNA Interactive Ligands Using Solid Phase Synthesis
Presentation Type
Poster/Portfolio
Presenter Major(s)
Chemistry, Biomedical Sciences
Mentor Information
Toni Rice, riceto@gvsu.edu
Department
Chemistry
Location
Henry Hall Atrium 60
Start Date
13-4-2011 1:00 PM
End Date
13-4-2011 2:00 PM
Keywords
Life Science
Abstract
Higher-order DNA conformations can form within regions of DNA that are rich in guanines. Telomeric DNA located at the end of human chromosomes, is guanine-rich and can fold into tetraplex DNA. Compounds that should interact and stabilize telomeric DNA are being developed. Synthesis of heterocyclic compounds as monomeric units used for solid phase synthesis will be described. The intermediate monomeric units synthesized include Fmoc protected 4-amino-N-methyl-pyrrole-2-carboxylic acid and Fmoc protected 3-amino-benzoic acid. As long term goals, the monomeric units will be linked via polyamides by solid phase synthesis. The final cyclization reaction will be achieved via the use of peptide coupling reagents and obtained after cleavage from the resin.
Toward the Synthesis of Cyclic Heterocyclic Polyamides as Tetraplex DNA Interactive Ligands Using Solid Phase Synthesis
Henry Hall Atrium 60
Higher-order DNA conformations can form within regions of DNA that are rich in guanines. Telomeric DNA located at the end of human chromosomes, is guanine-rich and can fold into tetraplex DNA. Compounds that should interact and stabilize telomeric DNA are being developed. Synthesis of heterocyclic compounds as monomeric units used for solid phase synthesis will be described. The intermediate monomeric units synthesized include Fmoc protected 4-amino-N-methyl-pyrrole-2-carboxylic acid and Fmoc protected 3-amino-benzoic acid. As long term goals, the monomeric units will be linked via polyamides by solid phase synthesis. The final cyclization reaction will be achieved via the use of peptide coupling reagents and obtained after cleavage from the resin.