Event Title
Investigating the Effects of BIBR1532 and Related Analogs on Telomerase Activity in Human Prostate Cancer Cells
Presentation Type
Poster/Portfolio
Presenter Major(s)
Biomedical Sciences, Preprofessional Studies, Cell and Molecular Biology, Biology
Mentor Information
Suganthi Sridhar
Department
Biomedical Sciences
Location
Henry Hall Atrium 101
Start Date
10-4-2013 11:00 AM
End Date
10-4-2013 12:00 PM
Keywords
Health, Life Science
Abstract
Telomeres are double stranded repeats of DNA sequence that cap the ends of chromosomes and provide genetic stability and immortality to cancer cells. Uncontrolled cellular proliferation of cancer cells is associated with the maintenance of telomeres in DNA. In normal cells, the length of telomeres decrease with each successive cell division. When the length becomes too short the cells cannot divide and become senescent or die. Telomerase is an enzyme which prevents the degradation of telomeres by adding bases to the ends of the telomere. Cancer cells employ this enzyme telomerase to maintain immortality. Synthetic telomerase inhibitor, BIBR1532, has shown growth arrest in tumor cells. In our study, BIBR1532, a mixed-type competitive inhibitor, and its synthetic analogues were tested for proliferative activity. A total of 6 compounds were identified to be highly active against proliferation. Upon these results, current tests are being performed on the telomerase activity.
Investigating the Effects of BIBR1532 and Related Analogs on Telomerase Activity in Human Prostate Cancer Cells
Henry Hall Atrium 101
Telomeres are double stranded repeats of DNA sequence that cap the ends of chromosomes and provide genetic stability and immortality to cancer cells. Uncontrolled cellular proliferation of cancer cells is associated with the maintenance of telomeres in DNA. In normal cells, the length of telomeres decrease with each successive cell division. When the length becomes too short the cells cannot divide and become senescent or die. Telomerase is an enzyme which prevents the degradation of telomeres by adding bases to the ends of the telomere. Cancer cells employ this enzyme telomerase to maintain immortality. Synthetic telomerase inhibitor, BIBR1532, has shown growth arrest in tumor cells. In our study, BIBR1532, a mixed-type competitive inhibitor, and its synthetic analogues were tested for proliferative activity. A total of 6 compounds were identified to be highly active against proliferation. Upon these results, current tests are being performed on the telomerase activity.