Publication Date


First Advisor

Ruijie Liu


Diabetes is characterized by inadequate utilization of glucose due to a lack of insulin. Cardiomyopathy is defined as chronic disease of the heart muscle. A correlation between diabetes and the onset of cardiomyopathy has been suggested though a complete understanding of this relationship remains to be determined. Induction of diabetes within mice via the injection of streptozotocin will allow for thorough investigation of this correlation. Enhancement of the proteins ERK 1/2, via the deletion of genes DUSP 6/8, has been shown to be a protective agent against various heart pathologies. By inducing diabetes within both wild type and DUSP 6/8 knockout mice it could be determined if these proteins are protective against the development of diabetic cardiomyopathy. The goal of this study is to further explore the correlation between diabetes and cardiomyopathy, as well as investigate protective effects ERK 1/2 proteins may have on the development of diabetic cardiomyopathy.