In 2017, the World Health Organization reported that 10 million people were infected with tuberculosis, 1.6 million of whom died. Tuberculosis is caused by a bacterium called Mycobacterium tuberculosis, which primarily infects an individual’s lungs. Unfortunately, failure to adhere to the long and arduous drug regimen has contributed to the emergence of antibiotic-resistant strains of M. tuberculosis. Therefore, the need for novel antibiotics is imperative to saving millions of lives. Our lab has recently developed a family of diphenyl ureas that exhibited increased antimicrobial activity toward Mycobacterium. Reported herein is the continuation of our previous research involving the synthesis of compounds with increased ester chain lengths and varying substituents on the phenyl ring. Compounds were confirmed using NMR spectroscopy and tested for antimicrobial activity using disk diffusion assays.
Burghduf, Piper, "Structure-Activity Relationship of Novel Diphenyl Ureas Targeting Mycobacterium" (2020). Student Scholars Day Posters. 39.