Student Summer Scholars Manuscripts

First Advisor

Zeni Shabani


Taar1, Methamphetamine, CPP, MA, Shabani, CRISPR, addiction, genetics


Medicine and Health Sciences




Vulnerability to methamphetamine (MA) use is related to the genetics that mediate the aversive and rewarding effects of MA. According to the most recent research, a gene known as the trace-amine associated receptor 1 (TAAR1) seems to play protective role, meaning animals that have a functional version of the gene have very low voluntary MA intake. Our research worked with mice that have a non-functional version of the TAAR1 gene and mice that have the functional version of the gene TAAR1+/+ knocked in via the CRISPR-Cas9 method. We pharmacologically manipulated the gene and were able to show that TAAR1 receptor is necessary for the aversive effects of MA and other hypothermic effects.