Previous investigations have shown that MK~801, a non-competitive N-methyl-D- aspartate (NMDA) receptor antagonist, produced anterograde amnesia (AA) at doses that did not impair performance processes necessary for learning to occur. Furthermore, MK~80 1 did not produce retrograde amnesia (RA). Using active avoidance conditioning as the learning paradigm and a 2x2 factorial design, the present study examined whether MK-801 produced state-dependent learning (SDL) resulting in AA. Our results showed that MK~801 did not produce SDL. This suggested that AA produced by MK-801 cannot be due to SDL. These results combined with previous findings suggest tha tMK-801 specifically impaired learning processes.