Abstract
The promoter region for the Histidine decarboxylase gene (pHdc), which is required for synthesis of the neurotransmitter histamine, has been functionally identified in Drosophila melanogaster. A fusion between pHdc and the enhanced Green Fluorescent Protein (eGFP) has been made in a plasmid that will allow generation of transformant flies. These transgenic flies containing the pHdc-eGFP gene fusion can be studied to determine whether the pHdc region causes expression of enhanced Green Fluorescent Protein (eGFP) in histaminergic cells. This research will allow further analysis of the HDC promoter and be a useful tool for examining the physiology of histaminergic cells.
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