Anti-Americanism has reached an unsettling global high that has been manifested in everything from opinion polls to violent protests. Latin America is geopolitically important to the United States, while harboring anti-American sentiment. The history of U.S.-Latin America relations and the most recent public opinion polls are analyzed to unearth the roots of regional anti-Americanism. Two case studies include a country notorious for its blatant anti-Americanism (Venezuela) and a country traditionally allied with the United States (Mexico). Despite different political or historical relations with the United States, Latin American countries have come to an anti-American consensus.