Document Type
Capstone
Advisors
Dr. Guenter Tusch, tuschg@gvsu.edu
Embargo Period
12-19-2013
Abstract
Helicobacter pylori is a ubiquitous bacterium found in the human stomach. Its infection is linked to various gastroduodenal diseases including peptic ulcer and gastric cancer. Despite the fact that H.pylori is present in more than 50% of the global population, only approximately 20% of infected individuals develop severe diseases.
One of the unique applications of H.pylori study is that it can be used as a tool for tracing human migrations since humans coevolved with their microbiomes.
In this project, the diversity of bacteria and host in the H.pylori-human model was examined. Multilocus sequences from 7 housepeeking genes in 131 H.pylori strains were analyzed using the Multi Locus Sequence Typing (MLST) software on the GVSU quattro computer with dual 6-core Intel Xeons architecture. This project gives an insight into the mechanism of co-evolution between the host and the parasites.
ScholarWorks Citation
Kutsumi, Yuka, "Analysis of Virulence Factors of Helicobacter pylori Infection and Human Migration" (2013). Technical Library. 159.
https://scholarworks.gvsu.edu/cistechlib/159
