In Vivo Human Skeletal Muscle Glycogen Measured by Chemical Exchange Saturation Transfer (GlycoCEST) and ¹³C MRS at 7T

Authors

Theodore Towse, Grand Valley State UniversityFollow
Adienne Dula, Vanderbilt University
Samuel Bearden, Vanderbilt University
Edward Welch, Vanderbilt University
James Joers, Vanderbilt University
Seth Smith, Vanderbilt University
Bruce Damon, Vanderbilt University

Keywords

glycogen, glycoCEST, magnetic resonance imaging

Disciplines

Analytical, Diagnostic and Therapeutic Techniques and Equipment

Abstract

CEST is a molecular imaging technique that allows indirect detection of protons associated with mobile proteins. GlycoCEST is a variant of CEST for imaging tissue glycogen, the storage form of glucose. With glycoCEST, the -OH protons of glycogen are saturated, transfer the saturation to bulk water by way of chemical exchange which reduces the bulk water signal in proportion to the glycogen content. the purpose of this study was to determine the feasibility of glycoCEST imaging in human skeletal muscle at 7T. Our findings, although preliminary, suggest that glycoCEST imaging at 7T can be used to image muscle glycogen.

Comments

Copyright © ISMRM.

Original Citation

Towse, T., Dula, A., Bearden, S., Welch, E., Joers, J., Smith, S., & Damon, B. (n.d.). In Vivo Human Skeletal Muscle Glycogen Measured by Chemical Exchange Saturation Transfer (GlycoCEST) and 13C MRS at 7T. 1.

ScholarWorks Citation

Towse, Theodore; Dula, Adienne; Bearden, Samuel; Welch, Edward; Joers, James; Smith, Seth; and Damon, Bruce, "In Vivo Human Skeletal Muscle Glycogen Measured by Chemical Exchange Saturation Transfer (GlycoCEST) and ¹³C MRS at 7T" (2010). Peer Reviewed Articles. 55.
https://scholarworks.gvsu.edu/bms_articles/55