Circulating microRNAs in Plasma as Predictive Biomarkers for Parkinson's Disease: a New Paradigm
Cell and Molecular Biology
College of Liberal Arts and Sciences
Parkinsons disease (PD) is a complex neurological disorder caused by progressive loss of dopaminergic neurons, leading to motor, cognitive, and gastro-intestinal dysfunctions. Due to the subtle nature of its motor symptoms which current clinical diagnosis is majorly based on, neurodegeneration has reached a relatively advanced stage by the time of diagnosis. Here, we identify and develop a panel of circulating microRNA (miRNAs) in plasma as biomarkers for PD. The biomarkers achieve the predictive power of 91% sensitivity and 100% specificity.
10th Annual microRNA as Biomarkers and Diagnostics
Khoo, Sok Kean, "Circulating microRNAs in Plasma as Predictive Biomarkers for Parkinson's Disease: a New Paradigm" (2014). Faculty Scholarly Dissemination Grants. 871.