Carious Lesions, Hydroxyapatite, Acidogenic, Phosphopeptide, Periodontitis, Xerostomia


This study reviews the biological mechanisms and recent advances in preventive dentistry therapies that prevent the formation dental caries, covering both traditional and novel techniques. The techniques covered prevent the formation of dental caries through two therapeutic approaches, either promoting the remineralization of the hard tooth surface or regulating the level and composition of the oral biofilm present in the mouth. Traditional therapies covered include fluoride and calcium treatments that promote the remineralization of the tooth surface, and antibiotic therapies that attempt to regulate oral biofilm levels, such as chlorhexidine, essential oils, systemic antibiotics, and salivation stimulating therapies. Novel applications covered are therapies that utilize antimicrobial peptides, immunizations, and probiotics that may become important to dentistry in the near future. Dental caries management is a complex and dynamic process, but by reestablishing optimal oral health through preventive techniques, dentists can preserve tooth structures and avoid costly and extensive restorative treatments.