Breast cancer, 25-Hydroxyvitamin D, Vitamin D, Lifestyle Factors
Few studies have investigated vitamin D status in association with modifiable lifestyle factors and clinical characteristics among breast cancer patients, with no studies among Chinese women, who may be at higher risk of vitamin D deficiency. We aimed to evaluate circulating 25-hydroxyvitamin D (25(OH)D) levels in association with clinical and lifestyle factors among 1,940 Chinese breast cancer patients.
Participants included breast cancer cases aged 22–77 from a population-based case-control study conducted in Shanghai, China during 1996–1998 (n = 1,044) and 2002–2005 (n = 896). Circulating 25(OH)D levels were measured in plasma samples (95% collected ≤6 months post-diagnosis). Prevalence ORs and 95% CIs were derived from multinomial logistic regression models, adjusting for age, season, and other factors.
About 23% and 48% of women were vitamin D deficient (/L) or insufficient (30–50 nmol/L), respectively. Tumor characteristics were not associated with vitamin D status. Higher BMI was associated with increased odds of vitamin D deficiency (ORs (95% CIs): 1 (reference), 1.12 (0.85,1.47), and 1.57 (1.02,2.42), for
In the largest study to date, the prevalence of low vitamin D status was high among Chinese breast cancer patients and associated with higher BMI, smoking, and lower physical activity. Our findings support careful monitoring of vitamin D status and recommendations for supplementation and other lifestyle modifications that may improve vitamin D status in breast cancer patients.
Shi L, Nechuta S, Gao YT, Zheng Y, Dorjgochoo T, Wu J, Cai Q, Zheng W, Lu W, Shu XO. Correlates of 25-hydroxyvitamin D among Chinese breast cancer patients. PLoS One. 2014;9(1):e86467. http://dx.doi.org/https://doi.org/10.1371/journal.pone.0086467
Shi, Liang; Nechuta, Sarah; Gao, Yu-Tang; Zheng, Ying; Dorjgochoo, Tsogzolmaa; Wu, Jie; Cai, Qiuyin; Zheng, Wei; Lu, Wei; and Shu, Xiao Ou, "Correlates of 25-Hydroxyvitamin D among Chinese Breast Cancer Patients" (2014). Peer Reviewed Articles. 3.