Abstract

A novel series of 18 anthranilic acid derivatives has been prepared by the Organic Chemistry Department at Grand Valley State University. The structures of the compounds were confirmed by analytical and spectral data. The compounds were investigated in vitro for antimicrobial activity by use of the disc diffusion and minimum inhibitory concentration (MIC) method against more than 20 types of aerobic and anaerobic bacteria, yeast, and fungi. Compounds that exhibited significantly low MIC’s were then tested for their antibacterial effectiveness in the presence of human serum protein (HSP). Of the compounds tested, GV-­‐2, GV-­‐27, GV-­‐28, and GV-­‐32 showed substantially significant activity.