Date Approved

1999

Graduate Degree Type

Thesis

Degree Name

Health Sciences (M.H.S.)

Degree Program

Health Professions

Abstract

Hemostasis is dependent on the functioning of three systems: blood vessels, platelets, and plasma proteins. During vessel injury, platelets adhere, secrete the contents of granules and aggregate. Each event in platelet activation is dependent upon plasma membrane proteins and a deficiency in any one of the plasma membrane proteins leads to excessive bleeding. Pregnancy is described as a hypercoagulable state during which frequent bleeding abnormalities are observed. The mechanism of hypercoagulability is not yet known. In an attempt to shed light on the hypercoagulable state, this study compares the plasma membrane proteins between pregnant and non-pregnant females.

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