Event Title
Design and Synthesis of Inhibitory Molecules for Cancer-Linked Focal Adhesion Kinase
Presentation Type
Oral and/or Visual Presentation
Presenter Major(s)
Chemistry
Mentor Information
Laurie Witucki, wituckil@gvsu.edu
Department
Chemistry
Location
Kirkhof Center 2216
Start Date
13-4-2011 4:00 PM
End Date
13-4-2011 4:30 PM
Keywords
Health, Illness, and Healing, Life Science
Abstract
Focal Adhesion Kinase (FAK) is a non-receptor protein kinase that plays a critical role in the cell-signaling pathways that lead to many cellular processes. In cancers such as breast and prostate, this kinase is found to be upregulated, making FAK a great target for anticancer drug development. Focus in this lab has been to develop peptidomimetics to regulate the activity of this enzyme. Peptide substrates were first developed, and were modeled after a tyrosine-containing motif of the known FAK substrate, p130cas. In hopes of developing a FAK regulating molecule, we have designed and synthesized a variety of substrate derivatives.
Design and Synthesis of Inhibitory Molecules for Cancer-Linked Focal Adhesion Kinase
Kirkhof Center 2216
Focal Adhesion Kinase (FAK) is a non-receptor protein kinase that plays a critical role in the cell-signaling pathways that lead to many cellular processes. In cancers such as breast and prostate, this kinase is found to be upregulated, making FAK a great target for anticancer drug development. Focus in this lab has been to develop peptidomimetics to regulate the activity of this enzyme. Peptide substrates were first developed, and were modeled after a tyrosine-containing motif of the known FAK substrate, p130cas. In hopes of developing a FAK regulating molecule, we have designed and synthesized a variety of substrate derivatives.