Design and Synthesis of Inhibitory Molecules for Cancer-Linked Focal Adhesion Kinase

Presentation Type

Oral and/or Visual Presentation

Presenter Major(s)

Chemistry

Mentor Information

Laurie Witucki, wituckil@gvsu.edu

Department

Chemistry

Location

Kirkhof Center 2216

Start Date

13-4-2011 4:00 PM

End Date

13-4-2011 4:30 PM

Keywords

Health, Illness, and Healing, Life Science

Abstract

Focal Adhesion Kinase (FAK) is a non-receptor protein kinase that plays a critical role in the cell-signaling pathways that lead to many cellular processes. In cancers such as breast and prostate, this kinase is found to be upregulated, making FAK a great target for anticancer drug development. Focus in this lab has been to develop peptidomimetics to regulate the activity of this enzyme. Peptide substrates were first developed, and were modeled after a tyrosine-containing motif of the known FAK substrate, p130cas. In hopes of developing a FAK regulating molecule, we have designed and synthesized a variety of substrate derivatives.

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Apr 13th, 4:00 PM Apr 13th, 4:30 PM

Design and Synthesis of Inhibitory Molecules for Cancer-Linked Focal Adhesion Kinase

Kirkhof Center 2216

Focal Adhesion Kinase (FAK) is a non-receptor protein kinase that plays a critical role in the cell-signaling pathways that lead to many cellular processes. In cancers such as breast and prostate, this kinase is found to be upregulated, making FAK a great target for anticancer drug development. Focus in this lab has been to develop peptidomimetics to regulate the activity of this enzyme. Peptide substrates were first developed, and were modeled after a tyrosine-containing motif of the known FAK substrate, p130cas. In hopes of developing a FAK regulating molecule, we have designed and synthesized a variety of substrate derivatives.