Faculty Scholarly Dissemination Grants
Nitric oxide scavenger carboxy-PTIO impaired memory of avoidance conditioning in goldfish
Department
Psychology Department
College
College of Liberal Arts and Sciences
Date Range
2013-2014
Disciplines
Social and Behavioral Sciences
Abstract
The long-term potentiation (LTP), an activity-induced increase in the efficacy of neurotransmission, has long been conceived to be a physiological correlate of learning and memory. Investigations of synaptic transmission suggest that the postsynaptic N-methyl-D-aspartate (NMDA) receptor is the upstream mediator of LTP, while nitric oxide (NO), a retrograde messenger from postsynaptic neurons to presynaptic neuron, is the downstream mediator of LTP. Our previous studies showed that microinjections of NMDA receptor antagonist D-AP5 to the goldfish telencephalon prior to trainings impaired learning of avoidance conditioning in goldfish. However, microinjections of D-AP5 to the goldfish telencephalon immediately following trainings did not impair memory of avoidance conditioning. Carboxy-PTIO is a NO scavenger that prevents NO from reaching the presynaptic neurons. The present study investigated the effects of microinjections of carboxy-PTIO to the goldfish telencephalon immediately following trainings on avoidance conditioning. The results showed that microinjections of carboxy-PTIO to the goldfish telencephalon immediately following trainings impaired memory of avoidance conditioning.
Conference Name
Conference on Psychology and Social Harmony
Conference Location
Suzhou, China
ScholarWorks Citation
Xu, Xiaojuan and Zmolek, Katie, "Nitric oxide scavenger carboxy-PTIO impaired memory of avoidance conditioning in goldfish" (2014). Faculty Scholarly Dissemination Grants. 689.
https://scholarworks.gvsu.edu/fsdg/689
