Date Approved
4-26-2024
Graduate Degree Type
Project
Degree Name
Biomedical Sciences (M.H.S.)
Degree Program
Biomedical Sciences
First Advisor
Dr. Fataye Babasola
Academic Year
2023/2024
Abstract
Molybdenum is an essential element for living organisms and it participates in many enzymatic reactions. Galleria mellonella (wax-moth larva model) has many advantages such as it has the capacity to grow at a temperature of 37°C like mammals and has a vast deal of anatomical and functional similarities between the innate immune systems of mammals and insects. The aim of this study is to assess molybdenum toxicity in the Galleria mellonella model. Molybdenum was given via intrahaemocoelic injection or gavage (force-feeding) to track survival, melanization and activity. Histological procedures were also done by using common laboratory techniques of dissection, fixation, processing, and staining to look at the effects of molybdenum on the Malpighian tubule and the gut. At low dosage of molybdenum, it was found to have a higher survival rate, low melanization, higher activity rate and less effects on the malphagian tubules and gut. The current study suggested that small amounts of molybdenum enhance the survival of G. mellonella, but large amounts led to mortality and damage to its organs.
ScholarWorks Citation
Sobiech, indie, "The effects of Sodium Molybdate on the alimentary canal and toxicity in the Greater Wax Moth, Galleria mellonella" (2024). Culminating Experience Projects. 447.
https://scholarworks.gvsu.edu/gradprojects/447
