Keywords
BAV, heart, medicine, research, cardiology
Disciplines
Life Sciences
Mentor
Ruijie Liu, PhD
Abstract
Bicuspid aortic valve (BAV) disease is the most common congenital heart condition in the world, with a prevalence of 0.5 to 2.0 %, with the highest predominance in Caucasian men. This disease causes two leaflets to form instead of the typical three leaflet and can lead to many complications. This paper explores the global prevalence of BAV, highlighting observed variations between ethnicities and geographical background. It also examines the genetic factors contributing to the condition, including known hereditary patterns and emerging genetic insights. This review also addresses risk factors associated with BAV, such as environmental and developmental influences, as well as other complications that can arise. Treatment strategies, from surgical interventions to preventative measures, are discussed, along with the impact of BAV on life expectancy and quality of life. Current knowledge gaps in care management and relevant clinical trials. By integrating data on prevalence, genetics, treatment options, and outcomes, this analysis provides a comprehensive overview of BAV, aiming to enhance understanding and advocate for future research and more clinical trials.
ScholarWorks Citation
Sligh, Grace, "Understanding Bicuspid Aortic Valve: Global Prevalence, Genetic Factors, Long- Term Outcomes, Treatment Approaches and Knowledge Gaps" (2024). Honors Projects. 959.
https://scholarworks.gvsu.edu/honorsprojects/959
