Keywords

Diet, Dietary, Neurodegenerative Disease (NDD), Alzheimer’s disease (AD), Parkinson’s disease (PD), cognitive decline, aging population, Mediterranean diet, Modified Atkins Diet (MAD), Ketogenic diet, Neuroinflammation, Gut microbiome, inflammatory biomarkers, Vitamin D, probiotics, prebiotics

Disciplines

Life Sciences | Medicine and Health Sciences | Nutrition

Mentor

Natalie Laudicina

Abstract

As populations age, neurodegenerative diseases (NDD) become significantly more prevalent and impactful on patients and families. Clinical research has suggested a correlation between diet, gut health, neuroinflammation and mitochondrial dysfunction to the onset and development of specific and severe NDDs, especially Alzheimer’s disease (AD) and Parkinson’s disease (PD). This research focuses on the relationship behind the gut-brain axis, micronutrient status and how diet influences the development of both AD and PD. Ten randomized, controlled trials were analyzed from the literature to investigate the impact of these factors on the inflammatory, metabolic and antioxidant processes. The studies focused on the use of vitamin D, different diets, short-chain fatty acids and probiotics on patient outcomes and NDD progression. This research will help provide insight into what nutritional decisions across the lifespan form significant relationships with AD and PD.

Download

Share

COinS