Keywords
Tuberculosis, InhA, amino diphenyl amide, SAR, synthesis, biological testing, MIC, novel drug compounds, MDR-TB
Disciplines
Chemistry
Mentor
Matthew Hart
Abstract
Tuberculosis (TB) remains a major global health threat. The bacteria causing TB, Mycobacterium tuberculosis, has proven difficult to combat, as drug resistance (MDR-TB) continues to develop within the bacteria. Access to healthcare in developing countries complicates the treatment of TB and MDR-TB. The World Health Organization has declared TB a global health crisis and has called for the development of new therapies. Previously, we used AutoDock Vina software to design novel drugs targeting InhA, an enzyme involved in mycobacterial cell wall synthesis. This project focuses on synthesizing amino diphenyl amides (ADA) and screening them against Mycobacterium. The synthetic pathway enables the production of various ADA structures with different amine and aryl groups. Biological tests include antimicrobial susceptibility and minimum inhibitory concentration evaluations. The results will help classify these ADA molecules based on their effectiveness against bacteria. Structural trends from this screening will guide the design and synthesis of new ADA derivatives. By expanding the molecular library and optimizing active compounds, this research aims to discover more effective TB antibiotics.
ScholarWorks Citation
Spradlin, Chloe, "Synthesis and in vitro Evaluation of Potential Tuberculosis Antibiotics" (2026). Honors Projects. 983.
https://scholarworks.gvsu.edu/honorsprojects/983
