Keywords
Adolescent exercise, Cardiovascular disease, cancer, older chinese women
Disciplines
Clinical Epidemiology | Community Health and Preventive Medicine
Abstract
Background: Little is known regarding the role of early-life exercise, a potentially modifiable factor, in long-term adult morbidity and mortality. We utilized the Shanghai Women's Health Study (SWHS) to investigate adolescent exercise in association with cancer, cardiovascular disease (CVD), and all-cause mortality among middle-aged and older women.
Methods: The SWHS is a prospective cohort of 74,941 Chinese women ages 40 to 70 years recruited from 1996 to 2000. In-person interviews at enrollment assessed adolescent and adult exercise history, medical and reproductive history, and other lifestyle and socioeconomic (SES) factors. Mortality follow-up occurs via annual linkage to the Shanghai Vital Statistics Registry. Adjusted hazard ratios (HR) and 95% confidence intervals (CI) were derived from Cox regression models.
Results: Adjusting for birth year and other adolescent factors, adolescent exercise was associated with reduced risk of cancer, CVD, and total mortality [HRs (95% CI), 0.83 (0.72–0.95), 0.83 (0.70–0.98), and 0.78 (0.71–0.85), respectively for ≤1.33 hours (h)/week, and 0.83 (0.74–0.93), 0.62 (0.53–0.72), and 0.71 (0.66–0.77), respectively for >1.33 h/week (reference = none)]. Results were attenuated after adjustment for adult SES and lifestyle factors. Participation in sports teams was inversely associated with cancer mortality [HR (95% CI), 0.86 (0.76–0.97)]. Joint adolescent and adult exercise was associated with reduced risk of all-cause, CVD, and cancer mortality [HRs (95% CIs), 0.80 (0.72–0.89), 0.83 (0.69–1.00), and 0.87 (0.74–1.01), respectively], adjusting for adult/adolescent factors, and adolescence exercise only was inversely associated with cancer mortality [HR (95% CI), 0.84 (0.71–0.98)].
Conclusions: Adolescent exercise participation, independent of adult exercise, was associated with reduced risk of cancer, CVD, and all-cause mortality.
Impact: Results support promotion of exercise in adolescence to reduce mortality in later life.
Original Citation
Nechuta, S. J., Shu, X. O., Yang, G., Cai, H., Gao, Y.-T., Li, H.-L., Xiang, Y.-B., & Zheng, W. (2015). Adolescent Exercise in Association with Mortality from All Causes, Cardiovascular Disease, and Cancer among Middle-Aged and Older Chinese Women. Cancer Epidemiology and Prevention Biomarkers, 24(8), 1270–1276. https://doi.org/10.1158/1055-9965.EPI-15-0253
ScholarWorks Citation
Nechuta, Sarah J.; Shu, Xiao Ou; Yang, Gong; Cai, Hui; Gao, Yu-Tang; Li, Hong-Lan; Xiang, Yong-Bing; and Zheng, Wei, "Adolescent Exercise in Association with Mortality from All Causes, Cardiovascular Disease, and Cancer among Middle-Aged and Older Chinese Women" (2015). Peer Reviewed Articles. 4.
https://scholarworks.gvsu.edu/ph_articles/4
