Testing of Novel Antimicrobials to Fight Antibiotic Resistance

Presentation Type

Poster/Portfolio

Presenter Major(s)

Biomedical Sciences

Mentor Information

Robert Smart, smartr@gvsu.edu

Department

Chemistry

Location

Henry Hall Atrium 67

Start Date

13-4-2011 10:00 AM

End Date

13-4-2011 11:00 AM

Keywords

Health and Wellness, Health, Illness, and Healing

Abstract

Infectious diseases continue to be internationally rampant and a leading cause of mortality even with the use of antibiotics and vaccinations. In an effort to combat emerging bacterial antibiotic resistance, we synthesize chemical compounds and test for high activity against Gram-positive bacteria, such as methicillin resistant Staphylococcus aureus (MRSA). Our leading active compounds are subjected to a minimum inhibitory concentration (MIC) test and results containing a MIC of 8ug/ml or less are then tested for minimal binding to human serum protein (HSP). We analyze our active novel compounds through IR and NMR spectroscopy in order to corroborate the structural identity. We continue to search for an antibacterial compound that preserves its minimum inhibitory concentration after being combined with human serum protein as this would be highly effective in destroying disease causing bacteria in the clinical setting.

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Apr 13th, 10:00 AM Apr 13th, 11:00 AM

Testing of Novel Antimicrobials to Fight Antibiotic Resistance

Henry Hall Atrium 67

Infectious diseases continue to be internationally rampant and a leading cause of mortality even with the use of antibiotics and vaccinations. In an effort to combat emerging bacterial antibiotic resistance, we synthesize chemical compounds and test for high activity against Gram-positive bacteria, such as methicillin resistant Staphylococcus aureus (MRSA). Our leading active compounds are subjected to a minimum inhibitory concentration (MIC) test and results containing a MIC of 8ug/ml or less are then tested for minimal binding to human serum protein (HSP). We analyze our active novel compounds through IR and NMR spectroscopy in order to corroborate the structural identity. We continue to search for an antibacterial compound that preserves its minimum inhibitory concentration after being combined with human serum protein as this would be highly effective in destroying disease causing bacteria in the clinical setting.