Toward the Synthesis of Cyclic Heterocyclic Polyamides as Tetraplex DNA Interactive Ligands Using Solid Phase Synthesis

Presentation Type

Poster/Portfolio

Presenter Major(s)

Chemistry, Biomedical Sciences

Mentor Information

Toni Rice, riceto@gvsu.edu

Department

Chemistry

Location

Henry Hall Atrium 60

Start Date

13-4-2011 1:00 PM

End Date

13-4-2011 2:00 PM

Keywords

Life Science

Abstract

Higher-order DNA conformations can form within regions of DNA that are rich in guanines. Telomeric DNA located at the end of human chromosomes, is guanine-rich and can fold into tetraplex DNA. Compounds that should interact and stabilize telomeric DNA are being developed. Synthesis of heterocyclic compounds as monomeric units used for solid phase synthesis will be described. The intermediate monomeric units synthesized include Fmoc protected 4-amino-N-methyl-pyrrole-2-carboxylic acid and Fmoc protected 3-amino-benzoic acid. As long term goals, the monomeric units will be linked via polyamides by solid phase synthesis. The final cyclization reaction will be achieved via the use of peptide coupling reagents and obtained after cleavage from the resin.

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Apr 13th, 1:00 PM Apr 13th, 2:00 PM

Toward the Synthesis of Cyclic Heterocyclic Polyamides as Tetraplex DNA Interactive Ligands Using Solid Phase Synthesis

Henry Hall Atrium 60

Higher-order DNA conformations can form within regions of DNA that are rich in guanines. Telomeric DNA located at the end of human chromosomes, is guanine-rich and can fold into tetraplex DNA. Compounds that should interact and stabilize telomeric DNA are being developed. Synthesis of heterocyclic compounds as monomeric units used for solid phase synthesis will be described. The intermediate monomeric units synthesized include Fmoc protected 4-amino-N-methyl-pyrrole-2-carboxylic acid and Fmoc protected 3-amino-benzoic acid. As long term goals, the monomeric units will be linked via polyamides by solid phase synthesis. The final cyclization reaction will be achieved via the use of peptide coupling reagents and obtained after cleavage from the resin.