Effect of Altered Gravity on Rat Mammary Epithelial Cell Proliferation

Presentation Type

Poster/Portfolio

Presenter Major(s)

Cell and Molecular Biology

Mentor Information

Osman Patel, patelo@gvsu.edu

Department

Cell and Molecular Biology

Location

Kirkhof Center KC29

Start Date

13-4-2011 9:00 AM

End Date

13-4-2011 10:00 AM

Keywords

Environment, Health and Wellness, Life Science, Technology

Abstract

If the human race is ever to expand into space, humans will be required to reproduce in low gravity. Data collected to date reveals that altered gravity environment impairs lipogenesis in a lactating mammary gland. However, accelerated growth of the secretory epithelium of the mammary gland takes place during pregnancy. Therefore, the objective of this study is to determine the effects of hypergravity exposure from mid- to late pregnancy on pre-partum morphogenesis of the mammary gland epithelium. Pregnant rats were exposed to either 2g or 1g from days 11 to 20 of gestation (G20). Mammary tissue was collected at G20 and processed for antibody directed staining. Immunolocalization studies of Caspase 3 and P53 in HG exposed and control rats are completed and data from structure and component analysis will be presented.

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Apr 13th, 9:00 AM Apr 13th, 10:00 AM

Effect of Altered Gravity on Rat Mammary Epithelial Cell Proliferation

Kirkhof Center KC29

If the human race is ever to expand into space, humans will be required to reproduce in low gravity. Data collected to date reveals that altered gravity environment impairs lipogenesis in a lactating mammary gland. However, accelerated growth of the secretory epithelium of the mammary gland takes place during pregnancy. Therefore, the objective of this study is to determine the effects of hypergravity exposure from mid- to late pregnancy on pre-partum morphogenesis of the mammary gland epithelium. Pregnant rats were exposed to either 2g or 1g from days 11 to 20 of gestation (G20). Mammary tissue was collected at G20 and processed for antibody directed staining. Immunolocalization studies of Caspase 3 and P53 in HG exposed and control rats are completed and data from structure and component analysis will be presented.