Event Title
Kappa Opioid Regulation of Stress-Related Behavior
Presentation Type
Poster/Portfolio
Presenter Major(s)
Biopsychology
Mentor Information
Glenn Valdez, valdezg@gvsu.edu
Department
Psychology
Location
Kirkhof Center KC59
Start Date
13-4-2011 11:00 AM
End Date
13-4-2011 12:00 PM
Keywords
Life Science
Abstract
Anxiety disorders affect roughly 40 million American adults in a given year. Those suffering from anxiety disorders often experience additional stress-linked illnesses, such as depression. This study examined the role of the kappa opioid system in regulating stress-related behavior. Behavioral stress responses were examined in male Wistar rats using the elevated plus-maze following i.p. administration of opioid agonist U-50,488 (0 or 10 mg/kg). Subjects were pretreated with the kappa opioid antagonist nor-binaltorphimine (nor-BNI) prior to testing in the elevated plus-maze (0 or 20 mg/kg). Injections of 10 mg/kg U-50,488 significantly decreased percent open arm time compared to controls and was reversed by pretreatment with 20 mg/kg nor-BNI (F(1,44) = 6.10, p < 0.05). The results indicate a relationship between kappa opioid receptors and stress-related behaviors.
Kappa Opioid Regulation of Stress-Related Behavior
Kirkhof Center KC59
Anxiety disorders affect roughly 40 million American adults in a given year. Those suffering from anxiety disorders often experience additional stress-linked illnesses, such as depression. This study examined the role of the kappa opioid system in regulating stress-related behavior. Behavioral stress responses were examined in male Wistar rats using the elevated plus-maze following i.p. administration of opioid agonist U-50,488 (0 or 10 mg/kg). Subjects were pretreated with the kappa opioid antagonist nor-binaltorphimine (nor-BNI) prior to testing in the elevated plus-maze (0 or 20 mg/kg). Injections of 10 mg/kg U-50,488 significantly decreased percent open arm time compared to controls and was reversed by pretreatment with 20 mg/kg nor-BNI (F(1,44) = 6.10, p < 0.05). The results indicate a relationship between kappa opioid receptors and stress-related behaviors.