Kappa Opioid Regulation of Stress-Related Behavior

Presentation Type

Poster/Portfolio

Presenter Major(s)

Biopsychology

Mentor Information

Glenn Valdez, valdezg@gvsu.edu

Department

Psychology

Location

Kirkhof Center KC59

Start Date

13-4-2011 11:00 AM

End Date

13-4-2011 12:00 PM

Keywords

Life Science

Abstract

Anxiety disorders affect roughly 40 million American adults in a given year. Those suffering from anxiety disorders often experience additional stress-linked illnesses, such as depression. This study examined the role of the kappa opioid system in regulating stress-related behavior. Behavioral stress responses were examined in male Wistar rats using the elevated plus-maze following i.p. administration of opioid agonist U-50,488 (0 or 10 mg/kg). Subjects were pretreated with the kappa opioid antagonist nor-binaltorphimine (nor-BNI) prior to testing in the elevated plus-maze (0 or 20 mg/kg). Injections of 10 mg/kg U-50,488 significantly decreased percent open arm time compared to controls and was reversed by pretreatment with 20 mg/kg nor-BNI (F(1,44) = 6.10, p < 0.05). The results indicate a relationship between kappa opioid receptors and stress-related behaviors.

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Apr 13th, 11:00 AM Apr 13th, 12:00 PM

Kappa Opioid Regulation of Stress-Related Behavior

Kirkhof Center KC59

Anxiety disorders affect roughly 40 million American adults in a given year. Those suffering from anxiety disorders often experience additional stress-linked illnesses, such as depression. This study examined the role of the kappa opioid system in regulating stress-related behavior. Behavioral stress responses were examined in male Wistar rats using the elevated plus-maze following i.p. administration of opioid agonist U-50,488 (0 or 10 mg/kg). Subjects were pretreated with the kappa opioid antagonist nor-binaltorphimine (nor-BNI) prior to testing in the elevated plus-maze (0 or 20 mg/kg). Injections of 10 mg/kg U-50,488 significantly decreased percent open arm time compared to controls and was reversed by pretreatment with 20 mg/kg nor-BNI (F(1,44) = 6.10, p < 0.05). The results indicate a relationship between kappa opioid receptors and stress-related behaviors.