Down-Regulation of Genes Are Associated with Metastatic Prostate Cancer

Presentation Type

Poster/Portfolio

Presenter Major(s)

Cell and Molecular Biology

Mentor Information

Suganthi Sridhar

Department

Biomedical Sciences

Location

Henry Hall Atrium 94

Start Date

11-4-2012 9:00 AM

Keywords

Health

Abstract

The metastasis tumor suppressor protein CD82 is down-regulated in prostate cancer. Microarray studies have been done on CD82(+/-) cells in both tumor and prostate cancer cells. CD82 re-expression has been shown in microarray data to regulate other genes involved in the suppression of metastasis which include: ITGA1, BST2, and MMP10. ITGA1, BST2, and MMP10 were seen to be down-regulated in the microarray data and this data will be validated using Q-PCR. ITGA1 encodes the alpha 1 subunit of integrin receptors which is involved in integrin mediated cell-cell adhesion. BST2 encodes the bone marrow stromal cell antigen which may be involved in B-cell development. MMP10 encodes the matrix metalloproteinase 10 which is involved in the breakdown of extracellular matrices. We expect to see the same pattern of expression with these three genes (ITGA1, BST2, and MMP10) with the Q-PCR that were seen in microarray data.

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Apr 11th, 9:00 AM

Down-Regulation of Genes Are Associated with Metastatic Prostate Cancer

Henry Hall Atrium 94

The metastasis tumor suppressor protein CD82 is down-regulated in prostate cancer. Microarray studies have been done on CD82(+/-) cells in both tumor and prostate cancer cells. CD82 re-expression has been shown in microarray data to regulate other genes involved in the suppression of metastasis which include: ITGA1, BST2, and MMP10. ITGA1, BST2, and MMP10 were seen to be down-regulated in the microarray data and this data will be validated using Q-PCR. ITGA1 encodes the alpha 1 subunit of integrin receptors which is involved in integrin mediated cell-cell adhesion. BST2 encodes the bone marrow stromal cell antigen which may be involved in B-cell development. MMP10 encodes the matrix metalloproteinase 10 which is involved in the breakdown of extracellular matrices. We expect to see the same pattern of expression with these three genes (ITGA1, BST2, and MMP10) with the Q-PCR that were seen in microarray data.