The Effect of Hyperbaric Oxygen Treatment on Pulmonary Arteries
Presentation Type
Poster/Portfolio
Presenter Major(s)
Biomedical Sciences
Mentor Information
Francis Sylvester
Department
Biomedical Sciences
Location
Kirkhof Center KC 69
Start Date
11-4-2012 9:00 AM
Keywords
Life Science
Abstract
Hyperbaric oxygen therapy can be used as a treatment for poor wound healing. Specific effects of this therapy are still unknown and it has been postulated that it may be appropriate for other clinical uses. The purpose of this study is to determine the effect of hyperbaric therapy on the function of pulmonary arteries. Pulmonary arteries are of particular interest since they are located within an oxygen-rich environment in the lungs. Pig lungs are obtained from the local abattoir. After dissection, arterial rings undergo various hyperbaric treatments for 2 hours. The arteries are then mounted in isolated organ baths, coupled to force transducers to record changes in tension in response to potassium chloride (nonreceptor-mediated vasoconstrictor), phenylephrine (receptor-mediated vasoconstrictor), and sodium nitroprusside (vasodilator). After drug treatments, recordings are compared to determine if there are any effects on the physiological function of the arterial rings.
The Effect of Hyperbaric Oxygen Treatment on Pulmonary Arteries
Kirkhof Center KC 69
Hyperbaric oxygen therapy can be used as a treatment for poor wound healing. Specific effects of this therapy are still unknown and it has been postulated that it may be appropriate for other clinical uses. The purpose of this study is to determine the effect of hyperbaric therapy on the function of pulmonary arteries. Pulmonary arteries are of particular interest since they are located within an oxygen-rich environment in the lungs. Pig lungs are obtained from the local abattoir. After dissection, arterial rings undergo various hyperbaric treatments for 2 hours. The arteries are then mounted in isolated organ baths, coupled to force transducers to record changes in tension in response to potassium chloride (nonreceptor-mediated vasoconstrictor), phenylephrine (receptor-mediated vasoconstrictor), and sodium nitroprusside (vasodilator). After drug treatments, recordings are compared to determine if there are any effects on the physiological function of the arterial rings.